Fabrice Thalmann

Peroxidised phospholipid bilayers: insight from Coarse-Grained Molecular Dynamics simulations

Fabrice Thalmann — Wed, 06 Jan 2016 08:46:42 +0000

Soft Matter, 12, 263-271 (2016) Yachong Guo, Vladimir Baulin and Fabrice Thalmann An original coarse-grained model for peroxidised phospholipids is presented, based on the MARTINI lipid force field. This model results from a combination of thermodynamic modelling and structural information on the area per lipid, which have been made available recently. The resulting coarse-grained lipid molecules form stable bilayers, and a set of elastic coefficients (compressibility and bending moduli) is obtained. We compare the compressibility coefficient to the experimental values . Predictions for mechanical properties, membrane thickness and lateral distribution of hydroperoxide groups in the

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Strasbourg: Principles of Imaging for Membrane systems

Fabrice Thalmann — Sat, 29 Aug 2015 19:36:14 +0000

Dates: 30 November – 3 December 2015 Location: Institut Charles Sadron (23, Rue de Loess, 67034, Strasbourg, France) Core training courses will cover such topics as methodology, models, and statistical estimation and hypothesis tests. Essential background and computational models for modelling lipid bilayers and their interactions with nano-objects will also be provided. Given the large differences in background between experimental and theoretical/computational ESRs, training courses will aim to highlight these two areas at different levels. Principles of imaging for membrane systems Courses will be given by senior academics in Strasbourg. A three days introduction to theoretical and experimental aspects of optical and

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Physical Damage on Giant Vesicles Membrane as a Result of Methylene Blue Photoirradiation

Fabrice Thalmann — Mon, 10 Feb 2014 18:12:40 +0000

Biophys. J. 106 (1), 162-71 (2014) Omar Mertins, Isabel O.L. Bacellar, Fabrice Thalmann, Carlos M. Marques, Maurício S. Baptista, Rosangela Itri In this study we pursue a closer analysis of the photodamage promoted on giant unilamellar vesicles membranes made of dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), by irradiating methylene blue present in the giant unilamellar vesicles solution. By means of optical microscopy and electro-deformation experiments, the physical damage on the vesicle membrane was followed and the phospholipids oxidation was evaluated in terms of changes in the membrane surface area and permeability. As expected, oxidation modifies structural characteristics of the phospholipids that lead

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ESR8-S: Kinetics of nanoscale structural changes occurring in small unilamellar vesicles

Fabrice Thalmann — Thu, 05 Dec 2013 15:07:02 +0000

Experimental investigation of unilamellar vesicles using microscopy techniques Contact Monika Kluzek Description Experimental project on small unilamellar lipid vesicles (SUV) interacting with nanoparticles, with special emphasis on the use of transmission electron microscopy (cryo-TEM). This project will consist in elaborating, characterizing and studying in detail decorated liposomes, using state of the art techniques such as EM tomography and time controlled freezing. He/she will become the referent for the electron microscopy platform. Project start July 2014 Related research topics

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