Posts by Marco Werner published at ITN SNAL - Marie Curie Initial Training Network

High-Throughput 3D Visualization of Nanoparticles attached to the Surface of Red Blood Cells

Marco Werner — Wed, 26 Dec 2018 14:21:44 +0000

Nanoscale, December (2018) André Dias, Marco Werner, Kevin Ward, Jean-Baptiste Fleury, Vladimir A. Baulin Blood circulation is the main distribution route for systemic delivery and the possibility to manipulate red blood cells by attaching nanoparticles to their surface provides a great opportunity for cargo delivery into tissues. Nanocarriers attached to red blood cells can be delivered to specific organs by orders of magnitude faster than if diluted in the blood. Another ad-vantage is a shielding from recognition of the immune system, thereby increasing the efficiency of delivery. We present a high-throughput microfluidic method that can monitor the shape of drifting

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Study of melanin localization in the mature male Calopteryx haemorrhoidalis damselfly wings

Marco Werner — Sat, 28 Apr 2018 12:38:09 +0000

J. Synchrotron Rad. 25, 874-877 (2018) Vi Khanh Truong, Jitraporn Vongsvivut, Nipuni Mahanamanam Geeganagamage, Mark J. Tobin, Pere Luque, Vladimir A. Baulin, Marco Werner, Shane Maclaughlin, Russell J. Crawford and Elena P. Ivanova Damselflies Calopteryx haemorrhoidalis exhibiting black wings are found in the western Mediterranean, Algeria, France, Italy, Spain and Monaco. Wing pigmentation is caused by the presence of melanin, which is involved in physiological processes including defence reactions, wound healing and sclerotization of the insect. Despite the important physiological roles of melanin, the presence and colour variation among males and females of the C. haemorrhoidalis species and the localization of the pigment within the wing membrane remain poorly

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Dynamic studies of the interaction of a pH responsive, amphiphilic polymer with a DOPC lipid membrane

Marco Werner — Tue, 28 Feb 2017 17:53:52 +0000

Soft Matter, 13, 3690-3700 (2017) Sivaramakrishnan Ramadurai, Marco Werner, Nigel K.H. Slater, Aaron Martin, Vladimir A. Baulin, Tia Keyes Deeper understanding of the molecular interactions between polymeric materials and the lipid membrane is important across a range of applications from permeation for drug delivery to encapsulation for immuno-evasion. Using highly fluidic microcavity supported lipid bilayers, we studied the interactions between amphiphilic polymer PP50 and a DOPC lipid bilayer. As the PP50 polymer is pH responsive the studies were carried out at pH 6.5, 7.05 and 7.5, corresponding to fully, and partly protonated (pH 7.05 (pKa)) and the fully ionized states

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Thermal Tunneling of Homopolymers through Amphiphilic Membranes

Marco Werner — Fri, 24 Feb 2017 15:06:46 +0000

ACS Macro Lett., 6, pp 247–251 (2017) Marco Werner, Jasper Bathmann, Vladimir A. Baulin, and Jens-Uwe Sommer We propose a theory to predict the passive translocation of flexible polymers through amphiphilic membranes. By using a generic model for the potential felt by a monomer across the membrane we calculate the free energy profile for homopolymers as a function of their hydrophobicity. Our model explains the translocation window and the translocation rates as a function of chain hydrophobicity in quantitative agreement with simulation results. The potential model leads to a new adsorption transition where chains switch from a one-sided bound adsorbed state

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Dresden: courses on general polymer theory and simulation

Marco Werner — Wed, 02 Sep 2015 19:18:01 +0000

13 April 2016. Core training courses will cover such topics as methodology, models, and statistical estimation and hypothesis tests. Essential background and computational models for modelling lipid bilayers and their interactions with nano-objects will also be provided. Given the large differences in background between experimental and theoretical/computational ESRs, training courses will aim to highlight these two areas at different levels. Compact courses on general polymer theory and simulation Open for all ESRs and ERs. ERs are included in tutorials and course preparation activities. ESRs can be involved into existing programs such as the Dresden International Graduate School for Biomedicine and Bioengineering DIGS-BB.

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