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High-Throughput 3D Visualization of Nanoparticles attached to the Surface of Red Blood Cells

Nanoscale, December (2018)

André Dias, Marco Werner, Kevin Ward, Jean-Baptiste Fleury, Vladimir A. Baulin

Blood circulation is the main distribution route for systemic delivery and the possibility to manipulate red blood cells by attaching nanoparticles to their surface provides a great opportunity for cargo delivery into tissues. Nanocarriers attached to red blood cells can be delivered to specific organs by orders of magnitude faster than if diluted in the blood. Another ad-vantage is a shielding from recognition of the immune system, thereby increasing the efficiency of delivery. We present a high-throughput microfluidic method that can monitor the shape of drifting cells due to interactions with nanoparticles and characterize 3D dispersion of fluorescent silica nanoparticles at the surface of red blood cells. The combination of a fluorescence microscopy technique with image analysis demonstrates that silica nanoparticles adsorption to the surface of red blood cells is strongly influenced by electrostatic interactions. Reduced numbers of intact red blood cells with increasing nanoparticle concentration beyond a threshold indicates that there is a toxicity mechanism associated with nanoparticle adsorption at the surface of red blood cells.

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DOI: 10.1039/C8NR09960J


Vladimir Baulin

Universitat Rovira i Virgili (URV), Tarragona, Spain

Coordinator of SNAL network. Expertise is computer simulations and theory of soft matter systems. Research is focused on the topics in the theory of Soft matter, polymer physics. more...


André Dias

MSCA Early Stage Researcher at the Universitaet Frankfurt, Germany Nanotoxicity and in-vitro investigation of interaction of nanomaterials with living cells. more...

Marco Werner

Project manager of SNAL at the Universitat Rovira i Virgili, Tarragona, Spain Theory and simulations of interaction of nanoobjects with lipid membranes, more...

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