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Nanotopography as a trigger for the microscale, autogenous and passive lysis of erythrocytes

J. Mater. Chem. B, (19), 2785-2948 (2014)

Vy T. H. Pham, Vi Khanh Truong, David E. Mainwaring, Yachong Guo, Vladimir Baulin, Mohammad Al Kobaisi,   Gediminas Gervinskas, Saulius Juodkazis, Wendy R. Zeng, Pauline Doran, Russell J Crawford and Elena P. Ivanova

Microscale devices are increasingly being developed for diagnostic analysis although conventional lysis as an initial step presents limitations due to scale or complexity. Here, we detail the physical response of erythrocytes to surface nanoarchitecture of black Si (bSi) and foreshadow its potential in microanalysis. The physical interaction brought about by the spatial convergence of the two topologies: (a) the nanopillar array present on the bSi and (b) the erythrocyte cytoskeleton present on the red blood cells (RBC), provides spontaneous stress-induced cell deformation, rupture and passive lysis within an elapsed time from immobilisation to rupture of ~3 min. and without external chemical or mechanical intervention. The mechano-responsive bSi surface provides highly active yet autogenous RBC lysis and a prospect as a front-end platform technology in evolving micro-fluidic platforms for cellular analyses.

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DOI: 10.1039/C3SM52740A

Nanotopography

Elena Ivanova

Swinburne University, Australia

Expertise in Microbiology and Biotechnology/Nanobiotechnology. Design, fabrication and operation of planar micro-devices.->
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