J. Mater. Chem. B, 2 (19), 2785-2948 (2014)
Vy T. H. Pham, Vi Khanh Truong, David E. Mainwaring, Yachong Guo, Vladimir Baulin, Mohammad Al Kobaisi, Gediminas Gervinskas, Saulius Juodkazis, Wendy R. Zeng, Pauline Doran, Russell J Crawford and Elena P. Ivanova
Microscale devices are increasingly being developed for diagnostic analysis although conventional lysis as an initial step presents limitations due to scale or complexity. Here, we detail the physical response of erythrocytes to surface nanoarchitecture of black Si (bSi) and foreshadow its potential in microanalysis. The physical interaction brought about by the spatial convergence of the two topologies: (a) the nanopillar array present on the bSi and (b) the erythrocyte cytoskeleton present on the red blood cells (RBC), provides spontaneous stress-induced cell deformation, rupture and passive lysis within an elapsed time from immobilisation to rupture of ~3 min. and without external chemical or mechanical intervention. The mechano-responsive bSi surface provides highly active yet autogenous RBC lysis and a prospect as a front-end platform technology in evolving micro-fluidic platforms for cellular analyses.
Latest posts by Elena Ivanova (see all)
- Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite - 04/09/2017
- The susceptibility of Staphylococcus aureus CIP 65.8 and Pseudomonas aeruginosa ATCC 9721 cells to the bactericidal action of nanostructured Calopteryx haemorrhoidalis damselfly wing surfaces - 09/03/2017
- TV3 film in Terres de l’Ebre - 08/09/2015