Optical microscopy and microrheology of giant unilamellar vesicles interacting with nano-objects

  • Interests: Experimental Biophysics, Synthetic biology
  • Supervisors: Carlos Marques, André Schröder
  • Host institution: Institut Charles Sadron CNRS, Strasbourg, France

Mattia Morandi

Short Bio

Mattia Morandi is pursuing his Ph.D at the National Centre for Scientific Research (CNRS) in Strasbourg, France, where he is focusing on the effects of nano-sized objects in the permeability properties of model membranes. He obtained his B.Eng. in Biomedical Engineering at the University of Bologna, Italy, with a thesis on the effect of surface charge in the interface interaction between cellular membranes and mineral substrates. He then obtained his M.Sc. in Physics at the University of Ferrara, Italy, with an emphasis on biophysics and medical physics. During his M.Sc, he spent one year abroad as a special research student at Tohoku University, Japan, where he conducted the research for his dissertation, under the joint supervision of Prof. Giorgio Rispoli and Prof. Masayuki Imai. For his master project, he investigated membrane deformations and shape changes occurring in DOPC unilamellar vesicles upon application of a transmembrane ionic asymmetry, using confocal microscopy and surface modelling program to quantify vesicles shape.

His main research interests are focused on understanding and controlling membrane deformations and bilayer properties changes in lipid vesicles using chemical stimuli and nano sized objects, with the aim to replicate cell-like functionalities.

2014-present Marie Skłodowska-Curie Actions Early Stage Researcher
Centre national de la recherche Scientifique (CNRS), France
2011-2014 M.Sc. in Physics University of Ferrara, Italy
2007-2010 B.Eng. in Biomedical Engineering University of Bologna, Italy

Methods and techniques

SNAL Project

  • ESR7-S: Optical microscopy and microrheology of giant unilamellar vesicles interacting with nano-objects

    Experimental investigation of unilamellar vesicles and their dynamics Description Experimental project on the morphological and mechanical changes in lipid vesicles caused by exposure to the nano-objects, by means of epi- and confocal fluorescence studies. Emphasis will be put on understanding the influence of lipid composition, oxidation and investigating the membrane structure changes using ratiometric fluorescent probes. Starting date December 2014 Methods and ...

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    Work in progress.