Smart Nano-objects for Alteration of Lipid bilayers (SNAL) Initial Training Network is a multidisciplinary EU-funded 7th Framework Programme specially designed to provide scientific and transferable skill training and career development for early stage researchers and experienced researchers in the field of lipid research.

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ESR10-C: Bioengineering of membrane associating polymers and polymer-protein complexes

Investigation of membrane associating polymers, therapeutic nanoparticles and cell preservation experiments

Biotechnology and and bioengineering, experimental

Contact

Alex Chen

Objectives

  • A safe polymer technology, which can be fine-tuned to deliver a wide variety of payloads into cells for various applications.
  • Novel pH-responsive, biodegradable polymers will be synthesized to mimic the activity of viruses, both in their cell entry and endosomal escape mechanisms
  • Synthesis of functional polymers and nanoparticles to tailor interactions and permeability of lipid bilayers for biomedical applications.

Tasks and methodology

  • Characterisation of the membrane translocation properties of the materials with mammalian cells and with lipid vesicles.
  • Experimental investCelligation of the use of membrane permeating materials in biostabilisation in collaboration with Biopharma.
  • Investigate how materials designed in this project can be used to stabilise mammalian cells in order that they can be freeze-dried without loss of viability or functional activity.
  • The cell membrane translocation behaviour of complexes formed between membrane disruptive polymers and therapeutic proteins and nucleotides will be assessed.

Starting date

October 2014

Related research topics

Alex Chen

MSCA Early Stage Researcher at the University of Cambridge, UK Investigation of membrane associating polymers, therapeutic nanoparticles and cell preservation experiments more...
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