Toxicity of nano-objects on human cells models
André Dias is currently pursuing a PhD at the FORM lab at the Goethe University in Frankfurt am Main in collaboration with the REPAIR-lab in Johannes Gutenberg University in Mainz. His research project focuses on the study of the interactions between nanoparticles synthesized by the network and actual human cell models. André obtained his B.Sc. in Biochemistry at the University of Porto with an emphasis on nanoparticle synthesis and functionalization. He then proceeded to his M.Sc. in Biophysics and Bionanosystems at University of Minho. André undertook his graduation project at the NanoScience Center from the University of Copenhagen as part of the Erasmus Placemant program. During this time, he was able to expand his experience of surface functionalization techniques and protein immobilization on two- and three-dimensional micro- and nanostructures. He was later awarded a research scholarship at Instituto Pedro Nunes where he broadened his experience to electrochemical analysis of enzyme biosensors. His current area of interest is the interaction of nanostructures with human cells and how these structures can be used to improve or develop novel techniques for diagnostics or therapeutics.
09/2007-09/2011 B.Sc. in Biochemistry. Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, Porto, Portugal. Thesis: Synthesis and Functionalization of bioconconjugates of gold nanoparticles and anticancer agents. Supervisor: Dr. Eulália Pereira.
||Marie Skłodowska-Curie Actions Early Stage Researcher. Medical Center, Universitaet Frankfurt, Germany
||Research Scholarship.. LEC – Instituto Pedro Nunes. Rua Pedro Nunes, Coimbra, Portugal.
||M.Sc. Student (Erasmus Placement). Martinez Group – Bionano and Nanomedicine, Nano-Science Center, University of Copenhagen. Universitetsparken 5, 2100 Copenhagen-Ø, Denmark.
||M.Sc. in Biophysics and Bionanosystems. Escola de Ciências da Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. M.Sc. Thesis: Versatile Route to appproach nanoscale protein multiplexing. Supervisor: Dr. Karen L. Martinez (University of Copenhagen). Co-Supervisor: Dr. Paulo Coutinho.
- ESR11-F: Delivery of molecular payloads through primary human cell membrane
In-vitro experiments on living cells, toxicology studies
The goal is to compare and validate the synthetic lipid models to biologically relevant cell types and to investigate how different nano-objects interact with representative lipid single and bilayers compared to human cells with and without therapeutic incorporation.
Tasks and methodology
Cellular uptake of fluorescence-labelled ...Read more
- High-Throughput 3D Visualization of Nanoparticles attached to the Surface of Red Blood Cells
Nanoscale, December (2018)
André Dias, Marco Werner, Kevin Ward, Jean-Baptiste Fleury, Vladimir A. Baulin
Blood circulation is the main distribution route for ...
- The Effect of Coatings and Nerve Growth Factor on Attachment and Differentiation of Pheochromocytoma Cells
Materials, 11(1) 60 (2018)
Anna Orlowska, Pallale Tharushi Perera, Mohammad Al Kobaisi, Andre Dias,
Huu Khuong Duy Nguyen, Shahram Ghanaati, Vladimir A. Baulin, ...
- Sugar-based collagen membrane cross-linking increases barrier capacity of membranes
Clin. Oral Invest., (2017)
Po-ju Chia-LaiAnna OrlowskaSarah Al-MaawiAndre DiasYunxin ZhangXuejiu WangNiklas ZenderRobert SaderC. James KirkpatrickShahram Ghanaati
This study examines the permeability and ...
- Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices
J Mater Sci: Mater Med, 28, 188 (2017)
Simon Wend, Alica Kubesch, Anna Orlowska, Sarah Al-Maawi, Niklas Zender, Andre Dias, Richard J. ...
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