Smart Nano-objects for Alteration of Lipid bilayers (SNAL) Initial Training Network is a multidisciplinary EU-funded 7th Framework Programme specially designed to provide scientific and transferable skill training and career development for early stage researchers and experienced researchers in the field of lipid research.

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Investigation and characterization of RNA-loaded liposome vaccines

Experimental methods and characterisation techniques

Description

We have previously demonstrated that certain combinations of lipids within a liposome formulation enable the highly effective delivery of RNA liposome vaccines to cells. However, such formulations have to date only been prepared at laboratory scale and methods are required whereby they can be manufactured in sufficient quantities for clinical trials and eventual marketing. Such methods must enable the formulation of RNA in high yield, due to the high cost of both the active ingredient and the lipids involved in the formulation, and result in a thermally stable formulation in which liposomes neither agglomerate nor degrade. The efforts in this project will be focused on identifying improved liposome manufacturing methods.

Starting date October 2014

Related research topics

Amanda Chen

Whitaker International Fellow at the University of Cambridge, UK Investigation and characterization of RNA-loaded liposome vaccines, more...
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