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Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces

Materials 201811(4), 605 (2018); https://doi.org/10.3390/ma11040605

Jason V. Wandiyanto, Denver Linklater, Pallale G. Tharushi Perera, Anna Orlowska, Vi Khanh Truong, Helmut Thissen, Shahram Ghanaati, Vladimir A. Baulin, Russell J. Crawford, Saulius Juodkazis and Elena P. Ivanova

Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants.

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DOI: 10.3390/ma11040605

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Vladimir Baulin

Universitat Rovira i Virgili (URV), Tarragona, Spain


Coordinator of SNAL network. Expertise is computer simulations and theory of soft matter systems. Research is focused on the topics in the theory of Soft matter, polymer physics. more...

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    Elena Ivanova

    Swinburne University, Australia

    Expertise in Microbiology and Biotechnology/Nanobiotechnology. Design, fabrication and operation of planar micro-devices.->

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      Anna Orlowska

      MSCA Early Stage Researcher at the Universitaet Frankfurt, Germany Immune reaction models of biomaterials on living organisms. more...

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