Membrane-active peptides

Following recent theoretical predictions ([1], [2]) the combination of amino-acids in custom peptides that can lead to a certain membrane function can be predicted and tested in membrane experiments.

Design a particular sequence of amino-acids for specific membrane function.

Particular focus of the project

• Membrane-attaching peptides
• Enhancing permeability of lipid bilayers
• Crossing membranes
• Pore-forming peptides

Associated projects

• Association of polymers and small solute molecules with phospholipid membranes

  Theoretical physics, theory in soft matter, computer simulations Objectives In many cases the properties of cell membranes are modified through biopolymers and small solute molecules such as anesthetics or neurotransmitters. They can associate to membranes and significantly alter their structure, either thermodynamic state or induce reorganization in form of pores. The project aims to describe the fundamental ...

Related outreach activities

• Informal ESR meeting of ITN SNAL network 6/7 Novembre 20146-7 November 2014 – Roda de Barà, Tarragona, Spain The second article of the Press Release section will be dedicated to the two days spent in Tarragona and organized by the MSCA Early Stage Researchers (ESRs). This meeting aimed to point out the role of ESRs within the ITN-SNAL Network, its possibilities and ...Read more

Related SNAL publications

• Dynamic studies of the interaction of a pH responsive, amphiphilic polymer with a DOPC lipid membrane

  Soft Matter, 13, 3690-3700 (2017) Sivaramakrishnan Ramadurai, Marco Werner, Nigel K.H. Slater, Aaron Martin, Vladimir A. Baulin, Tia Keyes Deeper understanding of ...

• Thermal Tunneling of Homopolymers through Amphiphilic Membranes

  ACS Macro Lett., 6, pp 247–251 (2017) Marco Werner, Jasper Bathmann, Vladimir A. Baulin, and Jens-Uwe Sommer We propose a theory to predict ...

Project team

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Vladimir Baulin

Expertise is computer simulations and theory of soft matter systems. Research is focused on the topics in the theory of Soft matter, polymer physics.

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Latest posts by Vladimir Baulin (see all)

• Simulations of Protein Adsorption on Nanostructured Surfaces - 21/03/2019
• The Interaction of Giant Unilamellar Vesicles (GUVs) with the Surface Nanostructures on Dragonfly Wings - 12/01/2019
• High-Throughput 3D Visualization of Nanoparticles attached to the Surface of Red Blood Cells - 26/12/2018

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Yachong Guo

Research student at the Universitat Rovira i Virgili, Tarragona, Spain Theory and simulations of small solute molecules and their interactions with lipid membranes, more...

Latest posts by Yachong Guo (see all)

• Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite - 04/09/2017
• Apatite nanoparticles strongly improve red blood cell cryopreservation by mediating trehalose delivery via enhanced membrane permeation - 26/06/2017
• Peroxidised phospholipid bilayers: insight from Coarse-Grained Molecular Dynamics simulations - 06/01/2016

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Marco Werner

Project manager of SNAL at the Universitat Rovira i Virgili, Tarragona, Spain Theory and simulations of interaction of nanoobjects with lipid membranes, more...

Latest posts by Marco Werner (see all)

• High-Throughput 3D Visualization of Nanoparticles attached to the Surface of Red Blood Cells - 26/12/2018
• Study of melanin localization in the mature male Calopteryx haemorrhoidalis damselfly wings - 28/04/2018
• Dynamic studies of the interaction of a pH responsive, amphiphilic polymer with a DOPC lipid membrane - 28/02/2017