Theoretical physics, theory in soft matter, computer simulations
Contact
Objectives
The aim of this project is to understand the interactions of lipid membranes with nano-objects including functional biomimetic polymers, polymeric micelles, carbon nanotubes and polymer therapeutic complexes/conjugates to enable the intelligent design of novel materials with improved bilayer modifying properties. A full range of theoretical methods will be employed to improve our understanding of interactions between phospholipid bilayers and nano-objects. Construction of molecular models biomimetic polymers interacting with lipid bilayers. Combination of Monte Carlo with SCMF theory to study equilibrium and kinetics. Application of the models to study permeation of lipid bilayers by amphiphilic polymers and rupture of the bilayers.
Tasks and methodology
- Implementation of a hybrid Single Chain Mean Field theory with Monte Carlo simulations
- Construction of the models for polymer – bilayer interactions
Starting date
October 2014
Related research topics
- Interaction of peptides and proteins with membranes
- Self-assembly of interpolyelectrolyte complexes and their interaction with lipid membranes
- Translocation of nanoparticles, carbon nanotubes and polymers through bilayers
- Polymer micelles as drug carriers
- Permeability of lipid bilayers induced by polymers
- Bridging molecular simulation models and elastic theories for amphiphilic membranes - 03/07/2018
- Training in Dresden - 28/12/2016
- Training in Frankfurt - 24/02/2016
